Water → HCID 9793894, compound

In a 300 mL beaker was placed 5.78 g (57 mmol) of 3-morpholinone (I), 50% (w/w)sodium hydroxide (5.02 g, 63 mmol), 100 mL of water and a magnetic stir bar. The resulting solution was heated for 30 min at a gentle boil then cooled to room temperature. While the solution was stirring at room temperature, the glycolonitrile (40 percent aqueous, 8.13 g, 57 mmol) was added dropwise. The solution was stirred at room temperature for 1 h. at which time a 13C NMR indicated that the reaction was complete. 13C NMR (D2O): δ50.3, 53.4, 119.4, 179.7, 180.9 ppm.

1. temperatureThe resulting solution was heated for 30 min at a gentle boil
2. stirringThe solution was stirred at room temperature for 1 h. at which time a 13C NMR

ORD record

ord-929b1aa263b34593be9163eb49f63af8

Source dataset

uspto-grants-2003_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06627772B2