Trifluoroacetic acid methylene chloride → HCID 22990557, compound

HRID 1169291Notes

Reaction equation

HRID 1169291 reaction equation
[CH2:1]([N:8]([C:35](=[O:41])[C:36]([O:38][CH2:39][CH3:40])=[O:37])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]=[CH:18][CH:17]=2)=[CH:12][C:11]=1[O:26][CH2:27][C:28]([O:30]C(C)(C)C)=[O:29])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O.ClCCl>>[CH2:1]([N:8]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]=[CH:18][CH:17]=2)=[CH:12][C:11]=1[O:26][CH2:27][C:28]([OH:30])=[O:29])[C:35](=[O:41])[C:36]([O:38][CH2:39][CH3:40])=[O:37])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 91275795HCID 91275795, compound

Product 1

HCID 22990557HCID 22990557, compound

Procedure

A room temperature solution of Example 20D (300 mg, 0.54 mmol) in 1:1 TFA/dichloromethane was stirred for 2 hours and concentrated to provide the desired product.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-508bac32a25c4b479527ab5a2871f222
Source dataset
uspto-grants-2003_09
Patent number
US06627767B2

Reaction notes

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