反应详情

Into acetic acid (42 ml) were added dropwise under ice cooling sulfuric acid (28 ml), subsequently N-(2-(4-bromophenyl)ethyl)trifluoroacetamide (7.8 g) and paraformamide (1.27 g) and the resulting mixture was stirred overnight under a nitrogen atmosphere. The reaction mixture was poured into ice water and was extracted with ethyl acetate. The organic layer was washed with an aqueous solution of sodium hydrogen carbonate, water and an aqueous saturated solution of sodium chloride, and was then dried with anhydrous magnesium sulfate. The resulting organic layer was evaporated under reduced pressure to remove the solvent to obtain 7-bromo-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline (8.1 g) as a colorless oil.

1. extractionwas extracted with ethyl acetate
2. washThe organic layer was washed with an aqueous solution of sodium hydrogen carbonate, water
3. dry with materialan aqueous saturated solution of sodium chloride, and was then dried with anhydrous magnesium sulfate
4. customThe resulting organic layer was evaporated under reduced pressure
5. customto remove the solvent