HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)phenyl isocyanate → 4-(7-(4-Methylphenyl)-1,2,3,4-tetrahydroisoquinolin-2-ylcarbonylamino)benzyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)phenyl isocyanate | HCID 2733319 | — |
| Reactant | 1,2,3,4-Tetrahydro-7-(4-methylphenyl)isoquinoline | HCID 22990067 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(7-(4-Methylphenyl)-1,2,3,4-tetrahydroisoquinolin-2-ylcarbonylamino)benzyl chloride | HCID 22990081 | 93.7% |
Reaction Steps
A solution of 4-(chloromethyl)phenylisocyanate (0.38 g) in tetrahydrofuran was added dropwise under ice cooling into a solution of 7-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinoline (0.5 g) in tetrahydrofuran. The resulting mixture was stirred for one hour and was then evaporated to remove the solvent to obtain 4-(7-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinolin-2-ylcarbonylamino)benzyl chloride (0.82 g) as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06627651B1 |
| Source dataset | uspto-grants-2003_09 |
| ORD ID | ord-237683ebf3194279b24bb9d864b4de6f |
| Source note | uspto-grants-2003_09 |