HCID 22989954, compound → HCID 17823976, compound

HRID 1169386Notes

Reaction equation

HRID 1169386 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([C:12]2[CH2:13][CH2:14][O:15][C:16]3[CH:22]=[CH:21][C:20]([C:23]4[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][CH:24]=4)=[CH:19][C:17]=3[CH:18]=2)=[O:11])=[CH:5][CH:4]=1)#[N:2].[ClH:30].[CH2:31]([OH:33])[CH3:32].O1CCOCC1>>[ClH:30].[CH2:31]([O:33][C:1]([C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]([C:12]2[CH2:13][CH2:14][O:15][C:16]3[CH:22]=[CH:21][C:20]([C:23]4[CH:24]=[CH:25][C:26]([CH3:29])=[CH:27][CH:28]=4)=[CH:19][C:17]=3[CH:18]=2)=[O:11])=[CH:7][CH:8]=1)=[NH:2])[CH3:32]

Participants

3

Reactant 2

HCID 22989954HCID 22989954, compoundHCID 86759185HCID 86759185, compound

Product 1

HCID 17823976HCID 17823976, compound

Procedure

To N-(4-cyanophenyl)-7-(4-methylphenyl)-2,3-dihydro-1-benzooxepine-4-carboxamide (347 mg) was added a solution of 28% hydrogen chloride/ethanol/dioxane (5 ml). After the resulting mixture was stirred at room temperature for 20 hours, the precipitate was collected by filtration and was washed with ethyl acetate to obtain N-[4-(ethoxycarbonimidoyl)phenyl]-7-(4-methylphenyl)-2,3-dihydro-1-benzooxepine-4-carboxamide hydrochloride (369 mg) as yellow crystals.

Workup

  1. filtrationthe precipitate was collected by filtration
  2. washwas washed with ethyl acetate

Sources & evidence

ORD record
ord-0bb44e2fb88c44ef94f04d56dc2396d9
Source dataset
uspto-grants-2003_09
Patent number
US06627651B1

Reaction notes

Loading…