Benzyl 2-[4-(tert-butoxycarbonylamino)piperidin-1-yl]ethylcarbamate → 1,1-Dimethylethyl N-[1-(2-aminoethyl)-4-piperidinyl]carbamate

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Reaction Steps

A mixture of benzyl 2-[4-(tert-butoxycarbonylamino)piperidin-1-yl]ethylcarbamate (3.0 g), Pd-C (0.3 g), and ethanol (100 ml) was stirred vigorously for 3 days under a hydrogen atmosphere. Pd-C was removed by filtration, and the filtrate was concentrated under reduced pressure to obtain tert-butyl 1-(2-aminoethyl)-4-piperidinylcarbamate (2.4 g) as a colorless oily substance.

Provenance & Evidence