Methyl iodide → HCID 22990099, compound

Participants

Reaction Steps

To N-[4-(piperidinomethyl)phenyl]-7-phenyl-1,2,3,4-tetrahydronaphthalene-2-carboxamide (300 mg) dissolved in DMF (3 ml) was added methyl iodide (132 μl), and the resulting mixture was stirred at room temperature for 17 hours. The reaction mixture was mixed with ethyl acetate (100 ml), and the resulting precipitate was collected by filtration to obtain 1-[4-(7-phenyl-1,2,3,4-tetrahydronaphthalene-2-carboxamido)benzyl]-1-methylpiperidinium iodide (compound 83) (374 mg) as colorless crystals.

Provenance & Evidence