Toluene → 1-(Chloromethyl)-3-ethoxybenzene

HRID 1169483Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1169483
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7]O)[CH3:2].C1(C)C=CC=CC=1.S(Cl)([Cl:21])=O>N1C=CC=CC=1.C(OCC)(=O)C>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][Cl:21])[CH3:2]

Komponenten

6

Edukt 3

HCID 1140TolueneHCID 24386Thionyl ChlorideHCID 41861833-Ethoxybenzenemethanol

Produkt 1

HCID 220483721-(Chloromethyl)-3-ethoxybenzene

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1049PyridineKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a mixture of 3-ethoxybenzyl alcohol (4.15 g) and toluene (50 ml) were added one drop of pyridine and thionyl chloride (3.0 ml), and the resulting mixture was stirred at room temperature for one hour. The reaction mixture was diluted with ethyl acetate, washed successively with water, an aqueous saturated solution of sodium bicarbonate, water and an aqueous saturated solution of sodium chloride, and was then dried with anhydrous magnesium sulfate. The resulting organic layer was evaporated under reduced pressure to remove the solvent to obtain 3-ethoxybenzyl chloride (5.34 g) as an oil.

Aufarbeitung

  1. washwashed successively with water
  2. dry with materialan aqueous saturated solution of sodium bicarbonate, water and an aqueous saturated solution of sodium chloride, and was then dried with anhydrous magnesium sulfate
  3. customThe resulting organic layer was evaporated under reduced pressure
  4. customto remove the solvent

Quellen und Nachweise

ORD-Eintrag
ord-aadbb5ca8e3c4636964c3f7b7c85d839
Quelldatensatz
uspto-grants-2003_09
Patentnummer
US06627651B1

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