HCID 69655555, compound → HCID 69655272, compound

HRID 11695Notes

Reaction equation

HRID 11695 reaction equation
[CH2:1]([O:3][C:4](=[O:34])[CH:5]=[CH:6][C:7]1[C:12]([O:13][CH2:14][C:15]([N:17]2[CH2:22][C@H:21]([CH3:23])[N:20]([CH2:24][C:25]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=3)[CH2:19][C@H:18]2[CH3:32])=[O:16])=[CH:11][CH:10]=[C:9]([CH3:33])[N:8]=1)[CH3:2]>CCO.[Pt]=O>[CH2:1]([O:3][C:4](=[O:34])[CH2:5][CH2:6][C:7]1[C:12]([O:13][CH2:14][C:15]([N:17]2[CH2:22][C@H:21]([CH3:23])[N:20]([CH2:24][C:25]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=3)[CH2:19][C@H:18]2[CH3:32])=[O:16])=[CH:11][CH:10]=[C:9]([CH3:33])[N:8]=1)[CH3:2]

Participants

4

Reactant 1

HCID 69655555HCID 69655555, compound

Product 1

HCID 69655272HCID 69655272, compoundYield 92.2%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

To a solution of 3-(3-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-6-methyl-pyridin-2-yl)-acrylic acid ethyl ester (0.54 g, 1.15 mmol) in EtOH (5.0 mL) was added platinum oxide (0.050 g) and the mixture was hydrogenated at 45 psi for 90 minutes. The mixture was filtered through celite and concentrated in vacuo to give the title compound (0.50 g).

Workup

  1. filtrationThe mixture was filtered through celite and
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-6b530ae27a03433a835046ef5fcb8a26
Source dataset
uspto-grants-2006_08
Patent number
US07098212B2

Reaction notes

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