1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- → 4-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid ethyl ester

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The title compound was prepared from 5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid ethyl ester and N-(2-bromoethyl)phthalimide as described in Example 1. 1H NMR (CDCl3) δ 7.85(m, 4H), 7.75(m, 4H), 7.55-7.45(m, 2H), 7.4-7.35(m, 1H), 7.25-7.2(m, 1H), 4.2-4.0(m, 6H), 3.9-3.85(m, 1H), 3.65-3.55(m, 3H), 3.4(br s, 1H), 2.4(s, 3H), 2.4-2.35(m, 1H), 1.35-1.15(m, 3H). MS (ES) m/z 583(MNa)+

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