Hydrochloric Acid → HCID 68765811, Verbindung

HRID 1169594Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1169594
[Cl:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)=[CH:4][C:3]=1[CH2:22][NH:23][C:24]([NH:26][C:27]1[CH:28]=[N:29][C:30]([CH3:33])=[CH:31][CH:32]=1)=[O:25].[ClH:34].O1CCOCC1>CO>[ClH:1].[ClH:34].[ClH:1].[Cl:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][N:7]2[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)=[CH:4][C:3]=1[CH2:22][NH:23][C:24]([NH:26][C:27]1[CH:28]=[N:29][C:30]([CH3:33])=[CH:31][CH:32]=1)=[O:25]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 23658772HCID 23658772, Verbindung

Produkt 1

HCID 68765811HCID 68765811, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The tert tert-butyl 4-(4-chloro-3-((3-(6-methylpyridin-3-yl)ureido)methyl)benzyl)piperazine-1-carboxylate from above (954 mg, 2.01 mmol) was dissolved in 40 mL of methanol and treated with 10 mL of 4N HCl in dioxane (40.2 mmol) with stirring for 16 h. The solvents were removed to afford 1.13 g of 1-(2-chloro-5-(piperazin-1-ylmethyl)benzyl)-3-(6-methylpyridin-3-yl)urea trihydrochloride salt as a white solid.

Aufarbeitung

  1. customThe solvents were removed

Quellen und Nachweise

ORD-Eintrag
ord-6a86a3b6305747439437ce8daa082353
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07825120B2

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