HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminophenyl trifluoromethyl sulphone → (s)-5-Methyl-1-(3-methylpyrid-4-ylmethyl)-3-(4-trifluoromethanesulfonylphenyl)imidazolidine-2,4-dione trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminophenyl trifluoromethyl sulphone | HCID 136315 | — |
| Reactant | 3-Methylpyridine-4-carbaldehyde | HCID 1501880 | — |
| Reactant | (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-hydroxypropanoic acid | HCID 6541433 | — |
| Product | (s)-5-Methyl-1-(3-methylpyrid-4-ylmethyl)-3-(4-trifluoromethanesulfonylphenyl)imidazolidine-2,4-dione trifluoroacetate | HCID 87566774 | — |
Reaction Steps
The compound is prepared from 0.04 mmol of resin, 0.12 mmol of N-Fmoc-L-Ala(OH), 0.20 mmol of 3-methyl-4-pyridinecarboxaldehyde, and 0.10 mmol of 4-(trifluoromethanesulfonyl)aniline, in the same way as in Example 1. After purification by preparative LC-MS, 16 mg of expected product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07825115B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-1e9c67ae864745169dd3a1da14d00a5c |
| Source note | uspto-grants-2010_11 |