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4-Aminophenyl trifluoromethyl sulphone → (r)-5-Methyl-1-(3-methylpyrid-4-ylmethyl)-3-(4-trifluoromethanesulfonylphenyl)imidazolidine-2,4-dione trifluoroacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Aminophenyl trifluoromethyl sulphone | HCID 136315 | — |
| 反応物 | (2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-hydroxypropanoic acid | HCID 688637 | — |
| 反応物 | 3-Methyl-4-pyridinecarboxaldehyde | HCID 1501880 | — |
| 生成物 | (r)-5-Methyl-1-(3-methylpyrid-4-ylmethyl)-3-(4-trifluoromethanesulfonylphenyl)imidazolidine-2,4-dione trifluoroacetate | HCID 10075980 | — |
反応手順
The compound is prepared from 0.04 mmol of resin, 0.12 mmol of N-Fmoc-D-Ala(OH), 0.20 mmol of 3-methyl-4-pyridinecarboxaldehyde and 0.10 mmol of 4-(trifluoromethanesulfonyl)aniline, in the same way as in Example 1. After purification by preparative LC-MS, 6.3 mg of expected product are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07825115B2 |
| 出典データセット | uspto-grants-2010_11 |
| ORD ID | ord-fe867e4a83744dc8aa16df4b7927a4f5 |
| 出典メモ | uspto-grants-2010_11 |