4-Quinolinecarboxaldehyde → HCID 10009654, Verbindung

HRID 1169645Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1169645
[NH:1]([C:14]([O:16]CC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@@H:2]([C:11]([OH:13])=[O:12])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.[N:31]1[C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[C:34]([CH:41]=O)=[CH:33][CH:32]=1.[F:43][C:44]([F:56])([F:55])[S:45]([C:48]1[CH:54]=[CH:53][C:51]([NH2:52])=[CH:50][CH:49]=1)(=[O:47])=[O:46]>>[F:43][C:44]([F:56])([F:55])[C:11]([OH:13])=[O:12].[OH:10][C:7]1[CH:6]=[CH:5][C:4]([CH2:3][C@H:2]2[N:1]([CH2:41][C:34]3[C:35]4[C:40](=[CH:39][CH:38]=[CH:37][CH:36]=4)[N:31]=[CH:32][CH:33]=3)[C:14](=[O:16])[N:52]([C:51]3[CH:53]=[CH:54][C:48]([S:45]([C:44]([F:56])([F:43])[F:55])(=[O:47])=[O:46])=[CH:49][CH:50]=3)[C:11]2=[O:13])=[CH:9][CH:8]=1

Komponenten

4

Edukt 3

HCID 780724-QuinolinecarboxaldehydeHCID 1363154-Aminophenyl trifluoromethyl sulphoneHCID 6957988Fmoc-D-tyrosine

Produkt 1

HCID 10009654HCID 10009654, Verbindung

Versuchsvorschrift

The compound is prepared from 0.05 mmol of resin, 0.15 mmol of N-Fmoc-D-Tyr(OH), 0.25 mmol of 4-quinolinecarboxaldehyde and 0.125 mmol of 4-(trifluoromethanesulfonyl)aniline, in the same way as in Example 1. After purification by preparative LC-MS, 1.8 mg of expected product are obtained.

Aufarbeitung

  1. customAfter purification by preparative LC-MS, 1.8 mg of expected product
  2. customare obtained

Quellen und Nachweise

ORD-Eintrag
ord-487ae06736424a45af59737e16d11e19
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07825115B2

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