Sulfuric Acid → S-Methyl-S-(4-nitrophenyl)sulfoximine

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

23.65 g (127.7 mmol) (RS)-1-(methylsulphinyl)-4-nitrobenzene in 130 ml chloroform are treated with 9.32 g (143.4 mmol) sodium azide. The mixture is slowly treated with 32.4 ml of concentrated sulphuric acid at 0° C. and then slowly heated to 45° C. After 16 hrs, the mixture is cooled to room temperature, treated with ice-water and extracted with chloroform. This organic phase is discarded. The aqueous phase is basified with 2N NaOH solution and extracted with DCM. The combined organic phases are washed with saturated NaCl solution, dried (Na2SO4), filtered and concentrated. 17.17 g (88.4 mmol, corresponding to 63% of theor.) of the product is obtained.

Herkunft & Nachweise