(RS)-S-(4-nitrophenyl)-N-(2-methoxy-acetyl)-S-methylsulfoximide → (RS)-S-(4-aminophenyl)-N-(2-methoxy-acetyl)-S-methylsulphoximide

Participants

Reaction Conditions

Reaction Steps

107 mg (0.39 mmol) (RS)—S-(4-nitrophenyl)-N-(2-methoxy-acetyl)-S-methylsulphoximide is dissolved in 13.6 ml ethanol and treated with 40 mg palladium on activated charcoal (10% Pd). The mixture is stirred under hydrogen at normal pressure for 60 minutes at 24° C. The catalyst is filtered off and the solution concentrated. After chromatographic purification (silica gel, hexane/ethyl acetate (0-50% ethyl acetate)), 50 mg (53%) of the desired product is obtained.

Provenance & Evidence