Sodium hydride → HCID 59550877, compound

Participants

Reaction Conditions

Reaction Steps

100 mg (0.5 mmol) (RS)—S-(4-nitrophenyl)-S-methylsulphoximide in 4 ml dimethylformamide are treated at room temperature with 23.97 mg sodium hydride (55%, 0.55 mmol). The mixture is stirred for 30 minutes at room temperature and for 30 minutes at 50° C. After cooling to room temperature 0.063 ml (0.55 mmol) 4-morpholinylcarbonyl chloride are added. The mixture is stirred for 30 minutes at room temperature and for 2 hours at 50° C. and finally quenched with methanol. After chromatographic purification (silica gel, hexane/ethyl acetate (0-50% ethyl acetate)), 87 mg (0.28 mmol, corresponding to 56% of theor.) of the desired product is obtained.

Provenance & Evidence