(R)-(-)-2-Amino-1-propanol → (R)-2-(2-chloro-5-iodopyrimidine-4-ylamino)propan-1-ol

Participants

Reaction Steps

In the reaction of 2,4-dichloro-5-iodopyrimidine (3.0 g, 10.9 mmol) with (R)-2-amino-1-propanol (884 mg, 11.8 mmol) according to procedure 2, the desired product is obtained in 88% yield (1.6 g) after chromatographic purification (silica gel, dichloromethane/methanol (0% to 20% methanol)).

Provenance & Evidence