2-Thiopheneboronic acid → (R)-2-(2-chloro-5-(2-thienyl)pyrimidine-4-ylamino)propan-1-ol

Participants

Reaction Steps

In the reaction of (R)-2-(2-chloro-5-iodopyrimidine-4-ylamino)propan-1-ol (400 mg, 1.3 mmol) with thiophen-2-boronic acid (e. g.: Aldrich, Acros, Apin) (179 mg, 1.4 mmol) according to procedure 3, the desired product is obtained in 70% yield (240 mg) after chromatographic purification (silica gel, ethyl acetate/hexane (0%-100% ethyl acetate)).

Provenance & Evidence