HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → 2-(2-Chloro-5-iodopyrimidine-4-ylamino)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | 2,4-Dichloro-5-iodopyrimidine | HCID 263438 | — |
| Product | 2-(2-Chloro-5-iodopyrimidine-4-ylamino)ethanol | HCID 59550872 | 83% |
Reaction Steps
In the reaction of 2,4-dichloro-5-iodopyrimidine (2.0 g, 7.3 mmol) with 2-amino-ethanol (480 mg, 7.9 mmol) according to procedure 2, the desired product is obtained in 83% yield (1.8 g) after chromatographic purification (silica gel, dichloromethane/methanol (0% to 20% methanol)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07825128B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-f4c206d4c6da471eaaa5ab6aaad042e8 |
| Source note | uspto-grants-2010_11 |