HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Thiopheneboronic acid → 2-(2-Chloro-5-(2-thienyl)pyrimidine-4-ylamino)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Thiopheneboronic acid | HCID 2733960 | — |
| Reactant | 2-(2-Chloro-5-iodopyrimidine-4-ylamino)ethanol | HCID 59550872 | — |
| Product | 2-(2-Chloro-5-(2-thienyl)pyrimidine-4-ylamino)ethanol | HCID 58985704 | 82% |
Reaction Steps
In the reaction of 2-(2-chloro-5-iodopyrimidine-4-ylamino)-ethanol (300 mg, 1.0 mmol) with thiophen-2-boronic acid (140 mg, 1.1 mmol) according to procedure 3, the desired product is obtained in 82% yield (210 mg) after chromatographic purification (silica gel, ethyl acetate/hexane (0%-100% ethyl acetate)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07825128B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-ad2368b1e0b44ac08cb85e6434080041 |
| Source note | uspto-grants-2010_11 |