N-(2-aminoethyl)acetamide → N-[2-(2-chloro-5-iodopyrimidine-4-ylamino)ethyl]acetamide

Participants

Reaction Steps

In the reaction of 2,4-dichloro-5-iodopyrimidine (1.0 g, 3.6 mmol) with N-(2-aminoethyl)acetamide (e. g. ABCR, Aldrich) (0.42 mL, 3.9 mmol) according to procedure 2, the desired product is obtained in 71% yield (878 mg) after trituration of the crystals obtained with diethyl ether.

Provenance & Evidence