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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1169731Generated: October 30, 2026

L-Leucinol → (S)-2-(2-chloro-5-thiophen-3-yl-pyrimidine-4-ylamino)-4-methyl-pentan-1-ol

https://huagongshe.com/reaction/1169731

Reaction equation

Participants

RoleNameHCIDCharge
ReactantL-LeucinolHCID 111307—
Reactant2,4-Dichloro-5-iodopyrimidineHCID 263438—
ReactantThiophene-3-boronic acidHCID 581760—
Product(S)-2-(2-chloro-5-thiophen-3-yl-pyrimidine-4-ylamino)-4-methyl-pentan-1-olHCID 58985746—

Reaction Steps

Preparation according to procedures 2 and 3 with the use of 2,4-dichloro-5-iodopyrimidine, L-leucinol (Aldrich) and thiophen-3-boronic acid (Aldrich).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07825128B2
Source datasetuspto-grants-2010_11
ORD IDord-f90ae3f480174176bb7fd6fd7bb25163
Source noteuspto-grants-2010_11