2,4-Dichloro-5-iodopyrimidine → HCID 58985786, compound

HRID 1169739Notes

Reaction equation

HRID 1169739 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5](I)=[CH:4][N:3]=1.[NH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]([CH2:17][NH:18][C:19](=[O:27])[C:20]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=1)=[O:16].CC1(C)C(C)(C)OB([C:36]2[S:37][CH:38]=[CH:39][CH:40]=2)O1>>[Cl:1][C:2]1[N:7]=[C:6]([NH:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]([CH2:17][NH:18][C:19](=[O:27])[C:20]2[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=2)=[O:16])[C:5]([C:36]2[S:37][CH:38]=[CH:39][CH:40]=2)=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 2634382,4-Dichloro-5-iodopyrimidineHCID 107036284,4,5,5-Tetramethyl-2-(thiophen-2-yl)-1,3,2-dioxaborolaneHCID 67547052HCID 67547052, compound

Product 1

HCID 58985786HCID 58985786, compound

Procedure

Preparation according to procedures 2 and 3 with the use of 2,4-dichloro-5-iodopyrimidine, N-[(3-amino-propylcarbamoyl)-methyl]-4-methyl-benzamide and 4,4,5,5-tetramethyl-2-(2-thienyl)-1,3,2-dioxaborolane.

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-323b805ede614603a0410a544c819591
Source dataset
uspto-grants-2010_11
Patent number
US07825128B2

Reaction notes

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