2,4-Dichloro-5-iodopyrimidine → HCID 58985756, compound

HRID 1169740Notes

Reaction equation

HRID 1169740 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5](I)=[CH:4][N:3]=1.[C:10]([O:14][C:15](=[O:29])[C@@H:16]([NH:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:17][CH2:18][NH:19]C)([CH3:13])([CH3:12])[CH3:11].[S:30]1[CH:34]=[CH:33][CH:32]=[C:31]1B(O)O>>[C:10]([O:14][C:15](=[O:29])[C@@H:16]([NH:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:17][CH2:18][NH:19][C:6]1[C:5]([C:31]2[S:30][CH:34]=[CH:33][CH:32]=2)=[CH:4][N:3]=[C:2]([Cl:1])[N:7]=1)([CH3:13])([CH3:12])[CH3:11]

Participants

4

Reactant 3

HCID 2634382,4-Dichloro-5-iodopyrimidineHCID 27339602-Thiopheneboronic acidHCID 86615478HCID 86615478, compound

Product 1

HCID 58985756HCID 58985756, compound

Procedure

Preparation according to procedures 2 and 3 with the use of 2,4-dichloro-5-iodo-pyrimidine, (S)-2-tert-butoxycarbonylamino-4-methylaminobutyric acid tert-butyl ester and 2-thiophenboronic acid.

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-e2b2c9711fc2436aa6c5976a4a7d7d00
Source dataset
uspto-grants-2010_11
Patent number
US07825128B2

Reaction notes

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