2,4-Dichloro-5-iodopyrimidine → HCID 178478336, compound

HRID 1169742Notes

Reaction equation

HRID 1169742 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5](I)=[CH:4][N:3]=1.[NH:10]1[CH:14]=[C:13]([CH2:15][CH2:16][NH2:17])[N:12]=[CH:11]1.CC1(C)C(C)(C)OB([C:26]2[S:27][CH:28]=[CH:29][CH:30]=2)O1>>[Cl:1][C:2]1[N:7]=[C:6]([NH:17][CH2:16][CH2:15][C:13]2[N:12]=[CH:11][NH:10][CH:14]=2)[C:5]([C:26]2[S:27][CH:28]=[CH:29][CH:30]=2)=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 2634382,4-Dichloro-5-iodopyrimidineHCID 107036284,4,5,5-Tetramethyl-2-(thiophen-2-yl)-1,3,2-dioxaborolaneHCID 178419017HCID 178419017, compound

Product 1

HCID 178478336HCID 178478336, compound

Procedure

Preparation according to procedures 2 and 3 with the use of 2,4-dichloro-5-iodo-pyrimidine, 2-(1H-imidazol-4-yl)-ethylamine and 4,4,5,5-tetramethyl-2-(2-thienyl)-1,3,2-dioxaborolane.

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-a85a65b957f24cebbd6b5a6c2df12e09
Source dataset
uspto-grants-2010_11
Patent number
US07825128B2

Reaction notes

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