2,4-Dichloro-5-iodopyrimidine → HCID 58985776, compound

HRID 1169743Notes

Reaction equation

HRID 1169743 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5](I)=[CH:4][N:3]=1.[NH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15](=[O:23])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.CC1(C)C(C)(C)OB([C:32]2[S:33][CH:34]=[CH:35][CH:36]=2)O1>>[Cl:1][C:2]1[N:7]=[C:6]([NH:10][CH2:11][CH2:12][CH2:13][NH:14][C:15](=[O:23])[CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:5]([C:32]2[S:33][CH:34]=[CH:35][CH:36]=2)=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 2634382,4-Dichloro-5-iodopyrimidineHCID 107036284,4,5,5-Tetramethyl-2-(thiophen-2-yl)-1,3,2-dioxaborolaneHCID 10797831HCID 10797831, compound

Product 1

HCID 58985776HCID 58985776, compound

Procedure

Preparation according to procedures 2 and 3 with the use of 2,4-dichloro-5-iodopyrimidine, N-(3-amino-propyl)-2-phenyl-acetamide and 4,4,5,5-tetramethyl-2-(2-thienyl)-1,3,2-dioxaborolane.

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-b47f7c7c33cd426a86933767dda12a62
Source dataset
uspto-grants-2010_11
Patent number
US07825128B2

Reaction notes

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