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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1169754Generated: November 4, 2026

2-Thiopheneboronic acid → 3-(2-Chloro-5-thiophen-2-yl-pyrimidin-4-yloxy)-propionic acid tert-butyl ester

https://huagongshe.com/reaction/1169754

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Thiopheneboronic acidHCID 2733960—
Reactant3-(5-Bromo-2-chloro-pyrimidin-4-yloxy)-propionic acid tert-butyl esterHCID 59550880—
Product3-(2-Chloro-5-thiophen-2-yl-pyrimidin-4-yloxy)-propionic acid tert-butyl esterHCID 58985766—

Reaction Steps

Preparation according to procedure 11a with the use of 3-(5-Bromo-2-chloro-pyrimidin-4-yloxy)-propionic acid tert-butyl ester and 2-thienyl-boronic-acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07825128B2
Source datasetuspto-grants-2010_11
ORD IDord-dc5b7978fc414ef1b303525eb3c67453
Source noteuspto-grants-2010_11