反应详情

In the reaction of (R)-2-(2-chloro-5-(2-thienyl)pyrimidine-4-ylamino)propan-1-ol (178 mg, 0.7 mmol) with (RS)—S-(4-aminophenyl)-N-(ethoxycarbonyl)-S-methyl-sulfoximide (145 mg, 0.6 mmol) according to procedure 5a, the desired product is obtained in 27% yield (85 mg) after chromatographic purification (silica gel, ethyl acetate/hexane (0%-80% ethyl acetate)).