反应详情

In the reaction of 2-(2-chloro-5-(2-thienyl)pyrimidine-4-ylamino)ethanol (200 mg, 0.8 mmol) with (RS)—S-(4-aminophenyl)-N-(ethoxycarbonyl)-S-methyl-sulfoximide (173 mg, 0.7 mmol) according to procedure 5a, the desired product is obtained in 37% yield (120 mg) after chromatographic purification (silica gel, dichloromethane/methanol (0%-20% methanol)).