反应详情

In the reaction (S)-2-(2-chloro-5-thiophen-3-yl-pyrimidine-4-ylamino)-4-methyl-pentan-1-ol (312 mg, 1.00 mmol) with (RS)—S-(4-amino-phenyl)-N-(ethoxycarbonyl)-S-ethylsulfoximide (231 mg, 0.90 mmol) according to procedure 5b, the desired product is obtained in 59% yield (282 mg) after chromatographic purification (silica gel, dichloromethane/methanol (0%-10% methanol)).