反应详情

In the reaction of (R)-2-(2-chloro-5-thiophen-2-yl-pyrimidine-4-ylamino)-butan-1-ol (425 mg, 1.5 mmol) with (RS)—S-(4-amino-2-bromphenyl)-N-(ethoxycarbonyl)-S-methylsulfoximide (404 mg, 1.3 mmol) according to procedure 5b, the desired product is obtained in 47% yield (340 mg) after chromatographic purification (silica gel, dichloromethane/ethanol (0%-20% ethanol)).