反应详情

In the reaction of (R)-2-(2-chloro-5-(2-thienyl)pyrimidine-4-ylamino)propan-1-ol (185 mg, 0.7 mmol) with (R)—S-(4-aminophenyl)-N-(ethoxycarbonyl)-S-cyclo-propyl-sulfoximide (167 mg, 0.6 mmol) according to procedure 5a, the desired product is obtained in 26% yield (90 mg) after chromatographic purification (silica gel, dichloromethane/ethanol (0%-20% ethanol)).