(R)-2-(2-chloro-5-(2-thienyl)pyrimidine-4-ylamino)butan-1-ol → (R)-N-(ethoxycarbonyl)-S-(4-{[4-{[(R)-1-(hydroxymethyl)propyl]amino}-5-(2-thienyl)pyrimidine-2-yl]amino}phenyl)-S-cyclopropylsulfoximide

Participants

Reaction Steps

In the reaction of (R)-2-(2-chloro-5-(2-thienyl)pyrimidine-4-ylamino)butan-1-ol (270 mg, 0.95 mmol) with (R)—S-(4-aminophenyl)-N-(ethoxycarbonyl)-S-cyclo-propyl-sulfoximide (224 mg, 0.83 mmol) according to procedure 5c, the desired product is obtained in 40% yield (170 mg) after chromatographic purification (silica gel, dichloromethane/ethanol (0%-20% ethanol)).

Provenance & Evidence