(R)-2-(2-chloro-5-(2-thienyl)pyrimidine-4-ylamino)butan-1-ol → (S)-N-(ethoxycarbonyl)-S-(4-{[4-{[(R)-1-(hydroxymethyl)propyl]amino}-5-(2-thienyl)pyrimidine-2-yl]amino}phenyl)-S-cyclopropylsulfoximide

Participants

Reaction Steps

In the reaction of (R)-2-(2-chloro-5-(2-thienyl)pyrimidine-4-ylamino)butan-1-ol (300 mg, 1.06 mmol) with (S)—S-(4-aminophenyl)-N-(ethoxycarbonyl)-S-cyclo-propyl-sulfoximide (258 mg, 0.96 mmol) according to procedure 5c, the desired product is obtained in 47% yield (256 mg) after chromatographic purification (silica gel, dichloromethane/ethanol (0%-20% ethanol)).

Provenance & Evidence