(R)-2-(2-chloro-5-(2-thienyl)pyrimidine-4-ylamino)propan-1-ol → (RS)-N-(ethoxycarbonyl)-S-(4-{[4-{[(R)-2-hydroxy-1-methylethyl]amino}-5-(2-thienyl)pyrimidine-2-yl]amino}phenyl)-S-cyclopropylsulfoximide

Participants

Reaction Steps

In the reaction of (R)-2-(2-chloro-5-(2-thienyl)pyrimidine-4-ylamino)propan-1-ol (155 mg, 0.57 mmol) with (RS)—S-(4-aminophenyl)-N-(ethoxycarbonyl)-S-phenyl-sulfoximide (159 mg, 0.52 mmol) according to procedure 5c, the desired product is obtained in 43% yield (120 mg) after chromatographic purification (silica gel, dichloromethane/ethanol (0%-20% ethanol)).

Provenance & Evidence