反应详情

In the reaction of (R)-2-(2-chloro-5-(2-thienyl)pyrimidine-4-ylamino)butan-1-ol (151 mg, 0.53 mmol) with (RS)—S-(4-aminophenyl)-N-(ethoxycarbonyl)-S-phenylsulfoximide (147 mg, 0.48 mmol) according to procedure 5c, the desired product is obtained in 49% yield (130 mg) after chromatographic purification (silica gel, dichloromethane/ethanol (0%-20% ethanol)).