反应详情

In the reaction of 3-(2-chloro-5-(2-thienyl)pyrimidine-4-ylamino)propanol (154 mg, 0.57 mmol) with (RS)—S-(4-aminophenyl)-N-(ethoxycarbonyl)-S-methyl-sulfoximide (127 mg, 0.53 mmol) according to procedure 5b, the desired product is obtained in 29% yield (80 mg) after chromatographic purification (silica gel, hexane/ethyl acetate (50%-100% ethyl acetate)) and subsequent purification by HPLC.