(R)-2-(2-chloro-5-(2-thienyl)pyrimidine-4-ylamino)propan-1-ol → (RS)-N-(ethylcarbamoyl)-S-(4-{[4-{[(R)-2-hydroxy-1-methylethyl]amino}-5-(2-thienyl)pyrimidine-2-yl]amino}phenyl)-S-methylsulfoximide

Participants

Reaction Steps

In the reaction of (R)-2-(2-chloro-5-(2-thienyl)pyrimidine-4-ylamino)propan-1-ol (296.3 mg, 1.1 mmol) with (RS)—S-(4-aminophenyl)-N-(ethylcarbamoyl)-S-methylsulphoximide (241 mg, 1 mmol) according to procedure 5c, the desired product is obtained in 26% yield (133 mg) after chromatographic purification (silica gel, dichloromethane/ethanol (0%-20% ethanol)).

Provenance & Evidence