反应详情

In the reaction of (R)-2-(2-chloro-5-(2-thienyl)pyrimidine-4-ylamino)propan-1-ol (291.7 mg, 1.08 mmol) with (RS)—S-(4-aminophenyl)-N-(isopropylcarbamoyl)-S-methylsulphoximide (251 mg, 0.98 mmol) according to procedure 5c, the desired product is obtained in 39% yield (186 mg) after chromatographic purification (silica gel, dichloromethane/ethanol (0%-20% ethanol)).