(R)-2-(2-chloro-5-(2-thienyl)pyrimidine-4-ylamino)propan-1-ol → HCID 58985702, compound

Participants

Reaction Steps

In the reaction of (R)-2-(2-chloro-5-(2-thienyl)pyrimidine-4-ylamino)propan-1-ol (30.7 mg, 0.11 mmol) with (RS)—S-(4-aminophenyl)-N-(pyridin-3-ylcarbamoyl)-S-methylsulphoximide (30 mg, 0.1 mmol) according to procedure 5c, the desired product is obtained in 4% yield (2.3 mg) after chromatographic purification (silica gel, dichloromethane/ethanol (0%-20% ethanol) and HPLC).

Provenance & Evidence