Potassium Iodide → HCID 58985536, compound

Participants

Reaction Steps

50 mg (0.1 mmol) (RS)—S-(4-{[4-(cyclohexylamino)-5-(2H-tetrazol-5-yl)-pyrimidine-2-yl]amino}phenyl)-N-(ethoxycarbonyl)-S-methylsulfoximide, 18 mg (0.1 mmol) benzyl bromide, 71 mg (0.51 mmol) potassium carbonate and 17 mg (0.1 mmol) potassium iodide in 1.6 ml 2-butanone are stirred for 6 hours at 80° C. After cooling, the mixture is absorbed onto silica gel and purified chromatographically (DCM/EtOH 95:5). 43 mg (0.07 mmol; corresponding to 73% of theory) of the product is obtained.

Provenance & Evidence