Sodium ethoxide → (Rs)-s-(4-{[4-{[(r)-2-hydroxy-1-methylethyl]amino}-5-(2-thienyl)pyrimidine-2-yl]amino}phenyl)-s-methylsulfoximide

Participants

Reaction Steps

In the reaction of (RS)—N-(ethoxycarbonyl)-S-(4-{[4-{[(R)-2-hydroxy-1-methyl-ethyl]-amino}-5-(2-thienyl)pyrimidine-2-yl]amino}phenyl)-S-methylsulfoximide (94 mg, 0.2 mmol) with sodium ethylate (49 mg, 0.7 mmol) according to procedure 14, the desired product is obtained in 44% yield (35 mg) after chromatographic purification (silica gel, dichloromethane/methanol (9/1)).

Provenance & Evidence