Sodium ethoxide → (Rs)-s-ethyl-s-(4-{[4-{[(s)-1-(hydroxymethyl)-3-methylbutyl]amino}-5-(3-thienyl)pyrimidine-2-yl]amino}phenyl)sulfoximide

Participants

Reaction Steps

In the reaction of (RS)—N-(ethoxycarbonyl)-S-ethyl-S-(4-{[4-{[(S)-1-(hydroxy-methyl)-3-methylbutyl]amino}-5-(3-thienyl)pyrimidine-2-yl]amino}phenyl)-sulfoximide (265 mg, 0.50 mmol) with sodium ethylate (70 mg, 1.0 mmol) according to procedure 14, the desired product is obtained in 34% yield (77 mg) after chromatographic purification (silica gel, dichloromethane/methanol (9/1)).

Provenance & Evidence