HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium ethoxide → (r)-s-(4-{[4-{[(r)-1-(Hydroxymethyl)propyl]amino}-5-(2-thienyl)pyrimidine-2-yl]amino}phenyl)-s-cyclopropylsulfoximide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | (R)-N-(ethoxycarbonyl)-S-(4-{[4-{[(R)-1-(hydroxymethyl)propyl]amino}-5-(2-thienyl)pyrimidine-2-yl]amino}phenyl)-S-cyclopropylsulfoximide | HCID 24769515 | — |
| Product | (r)-s-(4-{[4-{[(r)-1-(Hydroxymethyl)propyl]amino}-5-(2-thienyl)pyrimidine-2-yl]amino}phenyl)-s-cyclopropylsulfoximide | HCID 58985571 | 81% |
Reaction Steps
In the reaction of (R)—N-(ethoxycarbonyl)-S-(4-{[4-{[(R)-1-(hydroxymethyl)propyl]-amino}-5-(2-thienyl)pyrimidine-2-yl]amino}phenyl)-S-cyclopropylsulfoximide with sodium ethylate according to procedure 14, the desired product is obtained in 81% yield after chromatographic purification (silica gel, dichloromethane/ethanol (0-10% ethanol)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07825128B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-f7ed61c76e864a0a96ad373403452941 |
| Source note | uspto-grants-2010_11 |