Methyl morpholine oxide → HCID 58985751, compound

Participants

Reaction Steps

(RS)—N(ethoxycarbonyl)-(4-{[4-{(3-hydroxybutyl)amino}-5-(thiophen-2-yl)-pyrimidin-2-yl]amino}phenyl)-S-methylsulfoximide (169 mg, 0.35 mmol) is dissolved in dichloromethane (15 ml) and N-methylmorpholin-N-oxid (123 mg, 1.05 mmol) and molecular sieve (4 A, 496 mg) is added. The mixture is stirred for 15 min at RT. Then tetrapropylammoniumperruthenat (6.3 mg, 0.018 mmol) is added, the reaction mixture is stirred for 24 h at RT. Additional tetrapropylammoniumperruthenat (10.4 mg, 0.03 mmol) is added and the reaction mixture is stirred for 24 h at RT. For workup the mixture is filtered through celite and washed with dichloromethane. The solvent is evaporated resulting in the crude product which is purified by column chromatography: 39 mg, 23%.

Provenance & Evidence