Hydrochloric Acid → HCID 57430045, compound

Participants

Reaction Steps

tert-Butyl 4-cyano-4-(6-methylpyridin-2-yl)piperidine-1-carboxylate (II-2) (5.41 g, 18 mmole) was added 4M HCl in dioxane (60 mL). The resulting reaction mixture was stirred for 2 h at rt. After this time, LCMS indicated that the reaction was completion. The reaction was concentrated to afford 4-(6-methylpyridin-2-yl)piperidine-4-carbonitrile dihydrochloride (II-3) as a white solid. Analytical LCMS: single peak (214 nm), 1.669 min. This product was used in next step without further purification.

Provenance & Evidence