HCID 57430073, compound → HCID 59003493, compound

Participants

Reaction Steps

A solution of tert-butyl 4-cyano4-(3-methylpyridin-2-yl)piperidine-1-carboxylate (2 g, 6.6 mmol) in methanol (70 mL containing 2 M ammonia) was reacted with Raney nickel (1 mL of 50% slurry in water) under 45 psi hydrogen for 24 hours. The catalyst was filtered off and washed thoroughly with methanol. Evaporation of solvent afforded the desired product: tert-butyl 4-aminomethyl)4-(3-methylpyridin-2-yl)piperidine-1-carboxylate: 1H NMR δ (ppm)(CDCl3): 8.44 (1 H, br s), 7.41 (1 H, d, J=7.4 Hz), 7.07 (1 H, br s), 3.80 (2 H, br s), 3.01 (4 H, br s), 2.66 (2 H, s), 2.48 (3 H, s), 1.62-1.54 (2 H, m), 1.44 (9 H, s).

Provenance & Evidence