2,6-Dichloropyridine → HCID 57430017, compound

Participants

Reaction Steps

2,6-Dichloropyridine was reacted with tert-butyl 4-cyanopiperidine-1-carboxylate, reduced using Raney nickel, acylated with 2,4-dichlorobenzoyl chloride, deprotected and then sulphonylated with 1-propane sulphonyl chloride using the method described in example 10-2 to afford the desired product: 2,4-dichloro-N-{[4-(6-chloropyridin-2-yl)-1-propylsulfonyl)piperidin-4-yl]methyl}benzamide: 1H NMR δ (ppm)(CDCl3): 7.69 (1 H, t, J=7.8 Hz), 7.63 (1 H, d, J=8.3 Hz), 7.40 (1 H, d, J=1.9 Hz), 7.32-7.30 (2 H, m), 7.24 (1 H, d, J=7.8 Hz), 6.94 (1 H, m), 3.89 (2 H, d, J=6.2 Hz), 3.48-3.40 (4 H, m), 2.91-2.89 (2 H, m), 2.29-2.23 (2 H, m), 1.99-1.95 (2 H, m), 1.88-1.81 (2 H, m), 1.06 (3 H, t, J=7.4 Hz), m/z (ES) 504, 506 (M+H).

Provenance & Evidence