1,1'-Thiocarbonyldiimidazole → HCID 59550995, compound

HRID 1169939Notes

Reaction equation

HRID 1169939 reaction equation
[CH:1]([N:4]1[C:12]2[C:7](=[C:8]([NH2:15])[CH:9]=[CH:10][C:11]=2[O:13][CH3:14])[CH:6]=[CH:5]1)([CH3:3])[CH3:2].[C:16](N1C=CN=C1)(N1C=CN=C1)=[S:17]>ClCCl>[CH:1]([N:4]1[C:12]2[C:7](=[C:8]([N:15]=[C:16]=[S:17])[CH:9]=[CH:10][C:11]=2[O:13][CH3:14])[CH:6]=[CH:5]1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 802641,1'-ThiocarbonyldiimidazoleHCID 59551030HCID 59551030, compound

Product 1

HCID 59550995HCID 59550995, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1-isopropyl-7-methoxy-1H-indol-4-ylamine (U) (1 eq) in dichloromethane was added 1,1′-thiocarbonyldiimidazole (1.2 eq). The reaction was stirred for 2 hrs at room temperature then evaporated to dryness. Further purification by column chromatography produced the pure desired product.

Workup

  1. customthen evaporated to dryness
  2. customFurther purification by column chromatography

Sources & evidence

ORD record
ord-745378970f4e4d7ba7686361b52627e6
Source dataset
uspto-grants-2010_11
Patent number
US07825148B2

Reaction notes

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